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Abstract
Treatment with drugs can cause lung disorders. Immune checkpoint inhibitors are often associated with organizing pneumonia. Capillary leak syndrome is a clinical form of drug-induced lung injury, a rare condition characterized by hemoconcentration, hypoalbuminemia, and hypovolemic shock. There have been no reports of multiple lung injury with immune checkpoint inhibitors, and although capillary leak syndrome alone has been reported in the past, there have been no reports of pulmonary edema as a complication. We report a 68-year-old woman who died of respiratory and circulatory failure due to pulmonary edema caused by capillary leak syndrome, preceded by organizing pneumonia induced by combination therapy with nivolumab and ipilimumab for postoperative recurrence of lung adenocarcinoma. Residual inflammation and immune abnormalities from prior immune-related pulmonary adverse events may have increased pulmonary capillary permeability, leading to marked pulmonary edema.
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Publication history
Accepted:
February 19,
2023
Received in revised form:
February 15,
2023
Received:
January 25,
2023
Publication stage
In Press Journal Pre-ProofFootnotes
CRediT Statement
Hiroaki Tachi: Writing—original draft.
Atsuhito Shibagaki, Shu Teshima, Midori Hanazawa, Shihori Matsukura: Data curation, Visualization.
Kei Shimizu: Conceptualization.
Yusuke Yamamoto: Supervision, Writing—review and editing.
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© 2023 Published by Elsevier Inc. on behalf of the International Association for the Study of Lung Cancer.
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