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This work was supported by TAIHO Pharmaceutical Co. Ltd (C2020-097), the Princess Takamatsu Cancer Research Fund 18-250 (S.S.K), JSPS KAKENHI Grant Number JP20K17215 (H.I.), 16K21746 (S.S.K.), JPJSBP120207408 (S.S.K.) and 22H03084 (S.S.K.), and the National Cancer Center Research and Development Fund 31-A-6 (S.S.K).
Declaration of interests
Y.K., T.H., J.L., and S.M report no conflicts of interest. H.I. reports grants from Amgen, Ono, Takeda, and Eisai and personal fees from Ono, Chugai, AstraZeneca, Merck, and Takeda. S.K. reports personal fees from MSD and Chugai. H.U. reports grants from Takeda and Boehringer Ingelheim. N.H. reports personal fees from Boehringer Ingelheim and AstraZeneca. K.G. reports grants from Merck, Takeda Pharmaceutical, Amgen, Astellas, AstraZeneca, Boehringer Ingelheim, Bristol-Myers Squibb, Chugai, Daiichi Sankyo, Eisai, Janssen, Kyowa Kirin, Lilly, Medical & Biological Laboratories, MSD, Novartis, Ono, Pfizer, Sumitomo Dainippon, Bayer, Haihe Biopharma, Ignyta, Kissei, Life Technologies Japan, Loxo Oncology, Merus, Pfizer, Spectrum Pharmaceuticals, Sysmex Corporation, Turning Point Therapeutics, and Taiho and grants and personal fees from Amgen, Astellas, AstraZeneca, Boehringer Ingelheim, Bristol-Myers Squibb, Blueprint Medicines, Chugai, Daiichi Sankyo, Eisai, Eli Lilly, Janssen, Merck, MS, Novartis, Ono, Taiho, and Takeda and personal fees from Amoy Diagnostics, Bayer, Guardant Health, Thermo Fisher Scientific, Medpace, and Otsuka. SSK reports research support from Boehringer Ingelheim, MiRXES, Johnson&Johnson, and Taiho Therapeutics, as well as personal fees (honoraria) from AstraZeneca, Boehringer Ingelheim, Bristol Meyers Squibb, Chugai Pharmaceutical, and Takeda Pharmaceuticals.
CRediT Authorship Contribution Statement
Yosuke Kagawa: Conceptualization, Investigation, Methodology, Formal analysis, Writing – original draft, and Visualization.
Takuma Hayashida, Jie Liu, Shunta Mori, Shogo Kumagai: Investigation.
Hibiki Udagawa: Methodology and Conceptualization.
Noboru Hattori and Koichi Goto: Writing – review & editing.
Susumu S. Kobayashi: Conceptualization, Investigation, Methodology, Formal analysis, Writing – original draft, Visualization, Supervision, Funding acquisition, and Project administration.
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