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Remarkable intracranial response to sotorasib in a patient with KRASG12C-mutated lung adenocarcinoma and untreated brain metastases: A case report

Open AccessPublished:November 06, 2022DOI:https://doi.org/10.1016/j.jtocrr.2022.100428
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      Abstract

      Sotorasib is a KRASG12C inhibitor that recently received approval for use in locally advanced or metastatic KRASG12C-mutated non-small cell lung cancer. CodeBreaK100, the phase II clinical trial leading to the approval of sotorasib, excluded patients with untreated brain metastases; there have been no reports describing efficacy of sotorasib on untreated brain metastases. We present a case of a patient with active untreated brain metastases with resulting disorientation and weakness who demonstrated radiographic response and complete resolution of neurologic symptoms with sotorasib. Our case illustrates the intracranial activity of sotorasib, but additional studies are needed to characterize the intracranial response rate and duration of response in these patients.

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